Should C282Y homozygotes with mild iron overload be treated?

Whether all patients with Central precocious puberty should be treated?

Extended Abstract   Precocious puberty is the appearance of secondary sexual characteristics before 8 years old in girls and 9 years old in boys. Precocious puberty is divided into 3 groups of central, peripheral and normal variants. Central precocious puberty is accompanied by activation of hypothalamic-pituitary-gonadal axis which causes increase in secretion of GnRH, and in turn increase i...

Iron overload without the C282Y mutation in patients with epilepsy.

To test the hypothesis that iron overload predisposes to epilepsy, transferrin saturation in 130 patients with epilepsy and sex and age matched 128 control subjects without epilepsy were studied. Mean transferrin saturation was significantly higher in the epilepsy group (39.9 (SD 19.6)%) than in the control group (29.1 (SD 14.9)%). Abnormally high transferrin saturations (men>60%, women>48%) we...

Clinical consequences of iron overload in hemochromatosis homozygotes.

Hereditary hemochromatosis is an autosomal recessive disorder characterized by hyperabsorption of dietary iron and accelerated recycling of iron by macrophages. Homozygosity for the disease trait occurs in approximately 5 per 1000 whites of northern European descent.1 The causative gene, designated HFE, was identified in 1996.2 Most individuals with hemochromatosis are homozygous for a guanine ...

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

INTRODUCTION HFE p.C282Y homozygosity is the most common cause of hereditary haemochromatosis. There is currently insufficient evidence to assess whether non-specific symptoms or hepatic injury in homozygotes with moderately elevated iron defined as a serum ferritin (SF) of 300-1000 µg/L are related to iron overload. As such the evidence for intervention in this group is lacking. We present her...

Mild obstructive sleep apnea syndrome should not be treated. Con.